As a centerfire cartridge, the .22 Hornet is most commonly used for hunting vermin, small-game, predators, and competition. More powerful than the .22 WMR and .17 HMR, the .22 Hornet boasts higher velocity with a heavier bullet. The centerfire aspect of the .22 Horney makes it to where it can be handloadable and reloadable, making it more versatile.